Actions and Means Involved

1. demonstrate the negative environmental impact of the use of copper compounds for the control of bacterial diseases of plants.
2. demonstrate the performances of the project anti-virulence peptides obtained by chemical and biotechnological synthesis, at laboratory, pilot and field scale. The new peptides will be used in compliance with REACH document of EU legislation and won’t cause any environmental impact while acting more efficiently against plant pathogenic bacteria in vitro, in vivo and into the fields than conventional copper compounds.
3. demonstrate the chemical stability of the anti-virulence peptides, produced by both chemical and biotechnological synthesis.
4. demonstrate the project technical validity for optimising the up-scaling of treatments with the innovative anti-infective peptides, from laboratory to pilot scale and to semi-industrial scale.
5. demonstrate the positive ecotoxicologial profile of the anti-infective peptides.
6. demonstrate the absence of side effects of the anti-virulence peptides on common molecular targets of living organisms, at laboratory, pilot and semi-industrial scale.
7. demonstrate the absence of a direct selection operated by the anti-virulence peptides towards the emergence of bacteria resistant to the anti-virulence peptides themselves, at laboratory, pilot and semi-industrial scale.
8. demonstrate the absence of an indirect selection operated by the anti-virulence peptides on CU- and
antibiotic-resistant bacteria, at laboratory, pilot and semi-industrial scale.
9. demonstrate the short term environmental benefits and the economical advantages from the
use of the anti-virulence peptides in the control of bacterial diseases of plants.
10. demonstrate the environmental and economical benefits deriving from the use of the project’s peptides.
11. coordinate and manage the project and disseminate the results of the project in view of a wide
application within EU.

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